Lamb Mannerheim's faith is shaken after a plane crash burns two-thirds of her body, and she shocks her small-town congregation when she publicly renounces God. As she sets out to experience the worldly pleasures of Las Vegas, she meets a bartender and a cynical lounge singer who help her check off as many dirty deeds as possible from her Napkin of Sin bucket list.

Thirty-seven year old Mavis Gary seems incapable of happiness. She has had one failed marriage with no romance in her immediate horizon. She ghosts writes a young adult series of books, which has just been canceled due to low sales. She is in the process of writing the last book, with which she is having a mental block. She lives vicariously through Kendall Strickland, the teenaged female heroine in her books, as like Kendall she believes her high school years were the best years of her life when she was the prom queen. When she receives news that her high school beau, Buddy Slade, and his wife, Beth Slade, have just had their first child, Mavis takes it as a sign that she and Buddy are meant to be together. As such, she devises a false pretense to travel from her Minneapolis home back her her old hometown of Mercury, Minnesota to reclaim Buddy from Beth. As Mavis slyly or not so slyly does whatever she can to hang out with Buddy, even in Beth's company if need be, she also runs into ...

Nerdy reserved bookworm Needy, and arrogant, conceited cheerleader Jennifer are best friends, though they share little in common. They share even less in common when Jennifer mysteriously gains an appetite for human blood after a disastrous fire at a local bar. As Needy's male classmates are steadily killed off in gruesome attacks, the young girl must uncover the truth behind her friend's transformation and find a way to stop the bloodthirsty rampage before it reaches her own boyfriend Chip.

A tale told over four seasons, starting in autumn when Juno, a 16-year-old high-school junior in Minnesota, discovers she's pregnant after one event in a chair with her best friend, Bleeker. In the waiting room of an abortion clinic, the quirky and whip-sharp Juno decides to give birth and to place the child with an adoptive couple. She finds one in the PennySaver personals, contacts them, tells her dad and step-mother, and carries on with school. The chosen parents, upscale yuppies (one of whom is cool and laid back, the other meticulous and uptight), meet Juno, sign papers, and the year unfolds. Will Juno's plan work, can she improvise, and what about Bleeker?